Hepatotoxicity of dextropropoxyphene.
نویسندگان
چکیده
منابع مشابه
Dextropropoxyphene induced hepatotoxicity mimicking biliary tract disease.
Three patients are described with recurrent jaundice, upper abdominal pain and rigors attributable to dextropropoxyphene hepatotoxicity. The diagnosis was established in each patient by rechallenge; post challenge hepatic histology is reported in two. Twelve previous patients with probable dextropropoxyphene hepatic toxicity have been described and are reviewed. In 10 of the 15 patients, a clin...
متن کاملInteraction between carbamazepine and dextropropoxyphene.
Serious side effects may result from the concurrent administration of the usual dosage of carbamazepine and dextropropoxyphene. Three cases are reported and the mechanisms and implications discussed.
متن کاملUse of analgesics in France, following dextropropoxyphene withdrawal
BACKGROUND In 2009, the European Medicines Agency recommended withdrawal of dextropropoxyphene (DXP); in March 2011 it was withdrawn from the market in France. Up until that time the combination dextropropoxyphene-paracetamol (DXP/PC) was widely used for analgesia. At withdrawal, French regulators recommended that DXP/PC be replaced by other step 2 analgesics, i.e. tramadol, codeine, or opium-c...
متن کاملEffect of restrictions on prescribing patterns for dextropropoxyphene.
Prescribing of compound analgesics containing dextropropoxyphene was limited to consultants only in a teaching hospital. Inpatient prescribing (mainly by junior staff) fell immediately to very low levels but outpatient prescribing (by consultants) fell more slowly to about one-third of the original level, suggesting that patients and doctors find dextropropoxyphene compounds useful. Prescriptio...
متن کاملSurvival after an overdose of Distalgesic (dextropropoxyphene and paracetamol).
The combination of dextropropoxyphene and paracetamol, marketed as Distalgesic, once a popular analgesic, is now less commonly prescribed. Each tablet contains 32-5mg of dextropropoxyphene and 325mg of paracetamol. Overdoses with this preparation were common in the late seventies, though nowadays are rarely seen. ' Overdoses of as little as twenty tablets very often led to death within thirty m...
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ژورنال
عنوان ژورنال: BMJ
سال: 1977
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6082.296-a